2022

Regulation of Heme Utilization and Homeostasis in Candida albicans.

Andrawes N, Weissman Z, Pinsky M, Moshe S, Berman J, and Kornitzer D. PLoS Genetics. 2022 Sep 9;18(9):e1010390. doi: 10.1371/journal.pgen.1010390

The Importance of Antimicrobial Resistance in Medical Mycology.

Gow N, Johnson C, Berman J, Coste A, Cuomo C, Perlin D, Biacnic T, Harrison T, Wiederhold N, Bromley M, Chiller T, and Edgar K. Nature Communications. In press.

An Orthologous Gene Coevolution Network Provides Insight into Eukaryotic Cellular and Genomic Structure and Function.

Steenwyk JL, Phillips MA, Yang F, Date SS, Graham TR, Berman J, Hittinger CT, and Rokas A. Science Advances. 2022 May 6;8(18):eabn0105. doi: 10.1126/sciadv.abn0105

Tackling the Emerging Threat of Antifungal Resistance to Human Health.

Fisher M, Alastruey-Izquierdo A, Berman J, Bicanic T, Bignell E, Bowyer P, Bromley M, Brüggemann R, Garber G, Cornely O, Gurr S, Harrison T, Kuijper E, Rhodes J, Sheppard D, Warris A, White L, Xu J, Zwaan B, and Verweij P.  Nature Reviews Microbiology. 2022 Mar 29; doi: 10.1038/s41579-022-00720-1

Microbial Communities Form Rich Extracellular Metabolomes That Foster Metabolic Interactions and Promote Drug Tolerance.

Yu JSL, Correia-Melo C, Zorrilla F, Herrera-Dominguez L, Wu MY, Hartl J, Campbell K, Blasche S, Kreidl M, Egger A-S, Messner CB, Demichev V, Freiwald A, Mullender M, Howell M, Berman J, Patil KR, Alam MT, and Ralser M. Nature Microbiology. 2022 Mar 21; doi: 10.1038/s41564-022-01072-5

2021

Aneuploidy Underlies Tolerance and Cross-Tolerance to Drugs in Candida parapsilosis.

Yang F, Lu H, Wu H, Fang T, Berman J, and Jiang YY. Microbiology Spectrum. 2021 Oct 6;e0050821. doi: 10.1128/Spectrum.00508-21

Adaptation to Fluconazole via Aneuploidy Enables Cross-Adaptation to Amphotericin B and Flucytosine in Cryptococcus neoformans.

Yang F, Gritsenko V, Lu H, Zhen C, Gao L, Berman J, Jiang YY. Microbiol Spectrum. 2021 Sep 29;e0072321. doi: 10.1128/Spectrum.00723-21

Tunicamycin Potentiates Antifungal Drug Tolerance via Aneuploidy in Candida albicans.

Yang F, Gritsenko V, Slor-Futterman Y, Gao L, Zhen C, Lu H, Jiang YY, and Berman J. mBio. 2021 Aug 31;12(4):e0227221. doi: 10.1128/mBio.02272-21

A Gene Coevolution Network Provides Insight Into Eukaryotic Cellular and Genomic Structure and Function.

Steenwyk JL, Phillips MA, Yang F, Date SS, Graham TR, Berman J, Hittinger CT, and Rokas A. bioRxiv. 2021 July 10; doi: 10.1101/2021.07.09.451830

Adaptive Resistance Mutations at Supra-Inhibitory Concentrations Independent of SOS Mutagenesis.

Gutierrez R, Ram Y, Berman J, Marques de Sousa KC, Nachum-Biala Y, Britzi M, Elad D, Glaser G, Covo S, and Harrus S. Mol Biol Evol. 2021 Jun 27; doi: 10.1093/molbev/msab196

Multifactorial Mechanisms of Tolerance to Ketoconazole in Candida albicans.

Xu Y, Lu H, Zho S, Li WQ, Jiang YY, Berman J, and Yang F. Microbiology Spectrum. 2021 Jun 23; doi: 10.1128/Spectrum.00321-21

The Fitness Costs and Benefits of Trisomy of Each Candida albicans Chromosome.

Yang F, Todd RT, Selmecki A, Jiang YY, Cao YB, and Berman, J. Genetics. 2021 April 9; doi: 10.1093/genetics/iyab056 

Adenosine Triphosphate Released by Candida albicans Is Associated with Reduced Skin Infectivity 

Zhang S, Edwards TN, Mogavero S, Mathers, AT, Hube B, Berman J, Bougnoux ME, D'Enfert C, Kaplan DH. J Invest Dermatology. 2021. Mar 28; doi: 10.1016/j.jid.2021.03.010

Combining Miconazole and Domiphen Bromide Results in Excess of Reactive Oxygen Species and Killing of Biofilm Cells

Tits J, Berman, J, Cammue BPA, and Thevissen K. Frontiers in Cellular and Developmental Biology. 2021 January 21; doi:10.3389/fcell.2020.617214

Combining Colistin and Fluconazole Synergistically Increases Fungal Membrane Permeability and Antifungal Cidality

Bibi M, Murphy S. Banhamou RI, Rosenberg A, Ulman A, Bicanic T, Fridman M, and Berman J. ACS Infectious Diseases. 2021 January 20; doi:10.1021/acsinfecdis.0c00721

2020

Impact of Tolerance to Fluconazole on Treatment Response in Candida albicans Bloodstream Infection

Levinson T, Dahan A, Novikov A, Paran Y, Berman J, and Ben‐Ami T. Mycoses. 2020 Sep 30; doi: 10.1111/myc.13191

Elevated Vacuolar Uptake of Fluorescently Labeled Antifungal Drug Caspofungin Predicts Echinocandin Resistance in Pathogenic Yeast.

Jaber QZ, Bibi M, Ksiezopolska E, Gabaldon T, Berman J, and Fridman M. ACS Central Science. 2020 Sep 9; doi: 10.1021/acscentsci.0c00813

Evaluation of Microsatellite Typing, ITS Sequencing, AFLP Fingerprinting, MALDI-TOF MS, and Fourier-Transform Infrared Spectroscopy Analysis of Candida auris.

Vatanshenassan M, Boekhout T, Mauder N, Robert V, Maier T, Meis JF, Berman J, Then E, Kostrzewa M, and Hagen F. Journal of Fungi. 2020 Aug 25; 6(3):146. doi: 10.3390/jof6030146

Identification of Essential Genes and Fluconazole Susceptibility Genes in Candida glabrata by Profiling Hermes Transposon Insertions

Gale AN, Sakhawala RM, Levitan A, Sharan R, Berman J, Timp W, and Cunningham KW. G3: Genes, Genomes, Genetics. 2020 Aug 3. doi:10.1534/g3.120.401595

Combination of Miconazole and Domiphen Bromide is Fungicidal Against Biofilms of Resistant Candida spp.

Tits J, Cools F, De Cremer K, De Brucker K, Berman J, Verbruggen K, Gevaert B, Cos P, Cammue BPA and Thevissen K. Antimicrobial Agents and Chemotherapy. 2020 July 20; doi:10.1128/AAC.01296-20

Comparing the Utility of in vivo Transposon Mutagenesis Approaches in Yeast Species to Infer Gene Essentiality.

Levitan A, Gale AN, Dallon EK, Kozan DW, Cunningham KW, Sharan R, and Berman J. Current Genetics. 2020 July 17; doi:10.1007/s00294-020-01096-6

Candida albicans Genetic Background Influences Mean and Heterogeneity of Drug Responses and Genome Stability During Evolution to Fluconazole.

Gertsein A and Berman J. mSphere. 2020 June 24; doi:10.1128/mSphere.00480-20

Peptide Self-Assembly is Linked to Antibacterial, but Not Antifungal, Activity of Histatin 5 Derivatives.

Schnaider L, Rosenberg A, Kreiser T, Kolusheva S, Gazit E and Berman J. mSphere. 2020 April 1; doi:10.1128/mSphere.00021-20

Drug Resistance and Tolerance in Fungi.

Berman J and Krysan DJ. Nat Rev Microbiol. 2020 February 11; 18:319-331. doi:10.1038/s41579-019-0322-2

Extracellular ATP Released from Candida albicans Activates Non-Peptidergic Neurons to Augment Host Defense.

Edwards T, Zhang S, Liu A, Cohen J, Zhou P, Mogavero S, Hube B, Berman J, Bougnoux M, Mathers A, Gaffen S, Albers KM, Koeber HR, Davis B, d'Enfert B and Kaplan DH. bioRxiv. 2020 January 28; doi:10.1101/2020.01.27.921049